In a world first, a University of Melbourne study has shown that topical oestrogen could help prevent HIV infection by blocking entry of the virus into the human penis.
The study to be published in PLoS ONE journal June 4 reveals that application of oestrogen to the human penis increased the thickness of the natural keratin layer on the skin, which could prevent HIV from infecting the male.
The epithelium of the human penis is richly supplied with oestrogen receptors suggesting it could respond to topical oestrogen.
Dr Andrew Pask from the Department of Zoology at the University of Melbourne analysed the tissue samples from 12 foreskins and made the discovery.
"This suggested that oestrogen could induce a thickening of the keratin layer of the foreskin epidermis in the same way as it acts in the vagina," said Dr Pask.
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